Probiotic are live microorganisms, which can confer a health benefit on the host when administered in adequate amounts. Probiotics has been considered as generally safe, but it has also been reported that probiotics had unwanted side effects. New probiotic strains should be evaluated for safety by testing for antibiotic resistance, toxin production and hemolytic potential, assessing metabolic activities and bile salt deconjugation, conducting human studies to evaluate side effects and post-market surveillance of commercial consumers, etc. Since the probiotic properties and safety of probiotics is dependent on the strain, each probiotic strain should be evaluated. Inadequate quality of probiotic products, such as mislabeling regard to incorporated probiotic strains and contamination, has been frequently reported in recent years.

Genomic–scale taxonomy can be used easily identify species, safety assessment and functional predicted. For rapid screening of potential probiotic strains, quality assurance and post-survillance of probiotic products, we present PROBIOTIC Evaluation Database for evaluating the genome sequence of probiotic strain or probiotic products.